Table 1.
Data for mean arterial pressure (MAP), renal perfusion pressure (RPP), and renal blood flow per left kidney wet weight (RBF/KW). Data are presented as mean ± SEM and were analyzed using a repeated-measures ANOVA. B, from before ischemia; I, during moderate ischemia; and A, 30 min after reperfusion using the time (P time) group treatment (P group) and the interaction between time and group treatment (P time × group); n = 6 to 8 per group.
| Measured factors | Groups | Gender | |||||
|---|---|---|---|---|---|---|---|
| Different time in males | Different time in females | ||||||
| B | I | A | B | I | A | ||
| MAP (mmHg) | Vehicle | 104.7 ± 4.1 | 125.2 ± 6.2 | 103.3 ± 4.7 | 101.9 ± 1.0 | 119.9 ± 4.2 | 108.1 ± 1.9 |
| A779 | 105.9 ± 0.9 | 130.4 ± 2.8 | 107.4 ± 3.4 | 103.9 ± 1.8 | 126.0 ± 2.1 | 107.6 ± 2.2 | |
| A779 + PD123319 | 103.3 ± 1.4 | 129.8 ± 4.9 | 106.9 ± 2.9 | 101.5 ± 1.6 | 119.2 ± 3.6 | 107.7 ± 1.5 | |
| Analysis | Ptime < 0.0001, Pgroup = 0.64, Ptime × group = 0.87 | Ptime < 0.0001, Pgroup = 0.51, Ptime × group = 0.32 | |||||
| RPP (mmHg) | Vehicle | 94.8 ± 4.5 | 24.8 ± 0.8 | 95.1 ± 4.4 | 87.4 ± 1.9 | 23.9 ± 0.9 | 99.0 ± 2.4 |
| A779 | 96.4 ± 2.4 | 24.6 ± 0.9 | 101.9 ± 4.5 | 92.7 ± 2.5 | 23.3 ± 0.7 | 97.8 ± 3.5 | |
| A779 + PD123319 | 92.8 ± 2.0 | 23.2 ± 0.8 | 101.1 ± 3.5 | 88.5 ± 2.5 | 23.1 ± 0.5 | 98.8 ± 2.1 | |
| Analysis | Ptime < 0.0001, Pgroup = 0.58, Ptime × group = 0.42 | Ptime < 0.0001, Pgroup = 0.83, Ptime × group = 0.37 | |||||
| RBF/KW (mL/min.g tissue( | Vehicle | 2.73 ± 0.34 | 0.65 ± 0.04 | 2.82 ± 0.35 | 3.28 ± 0.32 | 0.90 ± 0.08 | 3.62 ± 0.38 |
| A779 | 3.26 ± 0.24 | 0.83 ± 0.06 | 3.0 ± 0.20 | 3.0 ± 0.22 | 0.80 ± 0.06 | 2.91 ± 0.21 | |
| A779 + PD123319 | 2.83 ± 0.25 | 0.70 ± 0.05 | 2.58 ± 0.25 | 3.06 ± 0.23 | 0.96 ± 0.06 | 2.82 ± 0.23 | |
| Analysis | Ptime < 0.0001, Pgroup = 0.51, Ptime × group = 0.65 | Ptime < 0.0001, Pgroup = 0.39, Ptime × group = 0.043 | |||||
A77, MasR antagonist; PD123319, AT2R antagonist.