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. 2019 Feb;14(1):36–45. doi: 10.4103/1735-5362.251851

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Copyright: © 2019 Research in Pharmaceutical Sciences

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Fig. 3 — Histological findings of brain sections of mice. Group A, RAPA + HSO/EPO-treated mice show (A₁) extensive infiltration of inflammatory cell, neurophagia, (A₂) spongy tissue, and (A₃) extensive demyelination; group B, RAPA-treated mice show (B₁) focal infiltration of inflammatory cells, (B₂) spongiotic zones, and (B₃) demyelination; group C, HSO/EPO-treated mice show (C₁) a few inflammatory cells (C_2,3) without spongy lesions and demyelination; group D, control EAE mice show (D₁) a great number of inflammatory cells, (D₂) extensive degeneration, spongy tissue, and (D₃) demyelination; group E, the section of the brain of naive mice exhibiting (E_1-3) no clinical signs. The first row was stained with H&E and the second and third rows were stained with LFB. EAE, experimental autoimmune encephalomyelitis; HSO/EPO, hemp seed oil/evening primrose oil; RAPA, rapamycin; H&E, hematoxylin and eosin; LFB, luxol fast blue.