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. 2018 Dec 4;21:51–67. doi: 10.1016/j.molmet.2018.11.012

Figure 1.

Figure 1

Schematic depicting exercise protocols for humans and mice. (A) Acute and chronic cyclying exercise was performed by healthy normoglycemic (control) and Dysglycemic (DG) men, age 40–65 years (N = 13/group). (B) Wildtype mice were studied during acute (EX45, EX90, EX90 + 3 h Rest) and chronic exercise (TRN, TRN + EX90) experiments 1–3. Exercise training (TRN) was achieved using voluntary running wheels for 30 days. Muscle was harvested 30 h after the last bout of exercise. An additional cohort of TRN mice performed an acute bout of moderate intensity treadmill running (TRN + EX90). (C) A panel of recombinant inbred strains of mice (84 strains of male and female mice, N = 4 mice/strain and a 15-strain subset of female mice, N = 4 mice/strain), the UCLA HMDP, were studied to determine the relationship between sex and Dnm1L expression and Dnm1L gene–gene relationships. (D) Muscle-specific Drp1 heterozygous (mDrp1+/−) mice were studied at rest and following EX90 and TRN.