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. 2018 Dec 4;21:51–67. doi: 10.1016/j.molmet.2018.11.012

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Alterations in gene and protein expression following chronic exercise training in female Control and mDrp1^+/− animals. (A) Quadriceps gene expression expressed as fold-change for mDrp1^+/⁻ TRN relative to Control TRN animals (two-tailed unpaired t-test; normalized to 18S). (B) Mitochondrial DNA copy number in quadriceps muscle of female Control (open bars) and mDrp1^+/− (closed bars) animals following TRN (two-tailed unpaired t-test). (C) Muscle protein expression in mDrp1^+/− relative to Control following TRN (two-tailed unpaired t-test; representative immunoblots presented in Supplemental Figure 2). Muscles were harvested from TRN mice 30 h following the cessation of exercise including a 6 h fast. Data are means ± SEM. N = 7–9/group. *, P < 0.05 mDrp1^+/− vs. Control.