Table 3.
Local Contral: Univariate Analysis
| Freedom from Local Failure (years from XRT) | |||||
|---|---|---|---|---|---|
| Covariate | Level | Number of Patients | HR (95% CI) | HR P Value | Log-Rank P Value |
| Number of lesions | >1 | 8 | 0.00 (0.00) | 0.993 | 0.488 |
| 1 | 203 | - | - | ||
| Location | Base of skull | 136 | 0.69 (0.21–2.26) | 0.541 | 0.539 |
| Other | 75 | - | - | ||
| XRT dose | ≥45 | 111 | 0.91 (0.28–3.00) | 0.879 | 0.879 |
| <45 | 100 | - | - | ||
| Treatment | FRT | 131 | 1.03 (0.30–3.53) | 0.963 | 0.963 |
| SRS | 80 | - | - | ||
| Median age at XRT | ≥58.5 | 106 | 1.03 (0.31–3.42) | 0.967 | 0.967 |
| <58.5 | 105 | - | - | ||
| Upper quartile age at XRT | ≥69.6 | 53 | 1.23 (0.25–5.94) | 0.799 | 0.798 |
| <69.6 | 158 | - | - | ||
| Median lesion size (average) | ≥5.30 | 92 | 1.68 (0.47–5.96) | 0.421 | 0.416 |
| <5.30 | 90 | - | - | ||
| Upper quartile lesion size (average) | ≥11.62 | 46 | 2.12 (0.60–7.52) | 0.246 | 0.235 |
| <11.62 | 136 | - | - | ||
| Median lesion size (sum) | ≥5.33 | 91 | 1.80 (0.51–6.40) | 0.365 | 0.358 |
| <5.33 | 91 | - | - | ||
| Upper quartile lesion size (sum) | ≥11.70 | 46 | 2.09 (0.59–7.41) | 0.256 | 0.245 |
| <11.70 | 136 | - | - | ||
| Age at XRT | 211 | 0.99 (0.95–1.04) | 0.754 | - | |
| Lesion size (average) | 182 | 1.03 (1.01–1.05) | 0.002 | - | |
| Lesion size (sum) | 182 | 1.03 (1.01–1.05) | 0.002 | - | |
HR, hazard ratio; CI, confidence interval; SRS, stereotactic radiosurgery; FRT, fractionated radiation therapy; XRT, radiation therapy.