Table 1.
Description of Study Groups and Treatment Regimens.
Study group | Baboon ID | Xeno-organs | Regimen |
---|---|---|---|
Study 1: Pilot study using available saved urine and kidney biopsy samples from three recipients of GalT-KO kidney | |||
Pilot study | B289 | Thymokidney | Anti-CD154 mAb-based regimen |
B314 | Thymokidney | Anti-CD154 mAb/rituximab-based regimen | |
B324 | Kidney + BM | ||
Study 2: Determine the effects of multiple doses of CTLA4-Ig treatment on the development of proteinuria following GalT-KO thymokidney transplantation in current (2013–2016) cases | |||
CTLA-4Ig group (2015–2016) | B393 | Thymokidney | Weekly doses of CTLA-4Ig + anti-CD154 mAb/rituximab-based |
B394 | regimen | ||
14P5 | |||
Comp: non-CTLA4-Ig group (2013–2014) | B341 | Thymokidney | Anti-CD154 mAb/rituximab-based regimen |
B358 | |||
B363 | |||
B366 |