Table 1. Overview of previously reported cases of CLL compromised by osteolytic bone lesions and/or hypercalcemia.
| Ref. | Age/Sex | Stage | WBC (109/L)/Lym | Hb (g/dL) |
Plt (109/L) |
M protein | Osteolytic bone lesions | Hypercalcemia | Treatment | Prognosis |
|---|---|---|---|---|---|---|---|---|---|---|
| 5 | 65/M | NA | 68.3/90% | 11 | 22 | Kappa | + | + | NA | NA |
| 6 | 73/F | NA | 2.8/78% | 9.3 | NA | NA | + | + | Chlor | 3 W Alive |
| 7 | 72/M | NA | 14.8/61% | 9.1 | 14.2 | NA | + | + | Chlor+PSL | 3 W Dead |
| 7 | 70/F | Binet C | NA/NA | NA | NA | NA | + | + | NA | 10 M Dead |
| 8 | 81/M | Binet A | NA/NA | NA | NA | Kappa | + | - | NA | NA |
| 9 | 60/M | NA | 3.52/57% | 12.7 | 6.2 | lambda | + | - | CHOP | 2 M Dead |
| 10 | 83/M | NA | NA/40X109/L | 10.1 | 21.3 | NA | + | + | CHOP | 6 M CR |
| 11 | 59/F | NA | NA/NA | NA | NA | NA | + | NA | FCR | Alive |
| 12 | 70/M | Rai III | 10.9/93.6% | 9.1 | 18.9 | Kappa | - | + | BR | Alive |
| Present | 40/F | Rai III | 6.5/65% | 7 | 12.4 | Kappa | + | + | FCR/BR | 2 Y Dead |
WBC, white blood cell; Lym, lymphocyte; Hb, hemoglobin; Plt, platelet; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisolone; Chlor, chlorambucil; FCR, fludarabine, cyclophosphamide, rituximab; BR, bendamustine, rituximab; PSL, prednisolone; CR, complete remission; NA; not available