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. 2019 Mar 5;12:1825–1839. doi: 10.2147/OTT.S176582

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© 2019 Zhou et al. This work is published and licensed by Dove Medical Press Limited

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Inhibition of USP4 exerted complex roles in MAPK pathway.

Notes: (A, B) Western blot was used to measure the expression level of p-ERK1/2, p-JNK and p-P38 in shUSP4- or NC-transduced U87 (A) and T98G (B) cells. (C, D) Western blot was used to measure the expression level of c-fos and p-c-fos in shUSP4- or NC-transduced U87 (C) and T98G (D) cells. ***P<0.001 compared to NC.

Abbreviations: NC, transduced with negative control; shUSP4, transduced with shUSP4 lentivirus; USP4, Ubiquitin-specific protease 4; WT, wild-type cells.