Table 2.
Baseline characteristics of the 1,228 patients with primary refractory or relapsed diffuse large B-cell lymphoma in the LYFO database in Denmark, 2000–2015, by treatment category
| Baseline characteristics | Total | None/palliation | Non-salvage | Salvage | P-value |
|---|---|---|---|---|---|
| 1,228 | 812 | 138 | 278 | ||
|
| |||||
| Age, years (median [range]) | 72 (18–100) | 75 (22–100) | 73 (27–92) | 60 (18–70) | |
|
| |||||
| Age, years | <0.001 | ||||
| <65 | 388 (32) | 173 (21) | 17 (12) | 198 (71) | |
| ≥65 | 840 (68) | 639 (79) | 121 (88) | 80 (29) | |
|
| |||||
| Sex | 0.1 | ||||
| Male | 667 (54) | 423 (52) | 79 (57) | 165 (59) | |
| Female | 561 (46) | 389 (48) | 59 (43) | 113 (41) | |
|
| |||||
| Period | <0.001 | ||||
| 2000–2004 | 360 (29) | 277 (34) | 24 (17) | 59 (21) | |
| 2005–2009 | 426 (35) | 243 (30) | 68 (49) | 115 (41) | |
| 2010–2015 | 442 (36) | 292 (36) | 46 (33) | 104 (37) | |
|
| |||||
| Previous rituximab | <0.001 | ||||
| No | 563 (46) | 424 (52) | 55 (40) | 84 (30) | |
| Yes | 665 (54) | 388 (48) | 83 (60) | 194 (70) | |
|
| |||||
| Primary refractory disease | <0.001 | ||||
| No | 610 (50) | 315 (39) | 110 (80) | 185 (66) | |
| Yes | 618 (50) | 497 (61) | 28 (20) | 93 (34) | |
|
| |||||
| Cohabitation status | <0.001 | ||||
| Single | 518 (42) | 391 (48) | 63 (46) | 64 (23) | |
| Couple | 710 (58) | 421 (52) | 75 (54) | 214 (77) | |
|
| |||||
| Educational level | <0.001 | ||||
| Short | 525 (43) | 363 (45) | 74 (54) | 88 (32) | |
| Medium | 404 (33) | 249 (31) | 37 (27) | 118 (42) | |
| Long | 179 (14) | 94 (11) | 21 (15) | 64 (23) | |
| Unknown | 120 (10) | 106 (13) | 6 (4) | 8 (3) | |
|
| |||||
| Disposable income | 0.3 | ||||
| Low | 287 (23) | 200 (25) | 34 (25) | 53 (19) | |
| Medium | 504 (41) | 334 (41) | 52 (38) | 118 (42) | |
| High | 437 (36) | 278 (34) | 52 (38) | 107 (39) | |
|
| |||||
| Comorbidities | <0.001 | ||||
| 0 | 459 (37) | 256 (32) | 49 (36) | 154 (55) | |
| 1 | 399 (33) | 269 (33) | 46 (33) | 84 (30) | |
| ≥2 | 370 (30) | 287 (35) | 43 (31) | 40 (14) | |
|
| |||||
| ASCT | |||||
| No | 1,254 | // | // | 133 (48) | |
| Yes | 144 | // | // | 144 (52) | |
Note: // Information is not relevant in the columns.
Abbreviation: ASCT, autologous stem cell transplant.