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PK parameters of TET and RPTNs in the rat after intravenous administration.
| Parameter | t1/2 (h) | MRT0–inf_obs (h) | Cmax (ng/mL) | AUC0–t (ng/ml h) | AUC0–inf_obs (ng/ml h) |
|---|---|---|---|---|---|
| TET | 6.56 ± 0.95 | 2.73 ± 0.50 | 434.93 ± 70.59 | 362.71 ± 66.24 | 370.11 ± 67.92 |
| RPTNs | 19.38 ± 1.93 | 27.18 ± 4.52 | 202.35 ± 19.21 | 657.28 ± 56.73 | 732.18 ± 55.36 |
