Table 2.
List of EV-associated proteins of the pathway haemostasis (1) and platelet signalling, activation and aggregation (2).
| Gene name | Protein name | FC | p | q | Pathway |
|---|---|---|---|---|---|
| ITGB1 | Integrin β-1 | 1.8 | 0.001 | 0.018 | 1 |
| CD63 | CD63 antigen | 1.7 | 0.003 | 0.019 | 1, 2 |
| BSG | Basigin | 1.6 | 0.001 | 0.018 | 1 |
| SLC16A3 | Monocarboxylate transporter 4 | 1.6 | 0.081 | 0.099 | 1 |
| CD47 | Leukocyte surface antigen CD47 | 1.5 | 0.004 | 0.021 | 1 |
| PRKAR2A | cAMP-dependent protein kinase type II-α regulatory subunit | 1.5 | 0.043 | 0.065 | 1 |
| RAC1 | Isoform B of Ras-related C3 botulinum toxin substrate 1 | 1.5 | 0.002 | 0.019 | 1, 2 |
| CALM1 | Calmodulin | 1.5 | 0.006 | 0.025 | 1, 2 |
| ITGAV | Integrin α-V | 1.5 | 0.003 | 0.019 | 1 |
| GNAS | Guanine nucleotide-binding protein G(s) subunit α isoforms Xlas | 1.5 | 0.006 | 0.025 | 1 |
| GNAI2 | Guanine nucleotide-binding protein G(i) subunit α-2 | 1.4 | 0.006 | 0.025 | 1, 2 |
| GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit β-1 | 1.4 | 0.001 | 0.018 | 1, 2 |
| A2M | α-2-macroglobulin | 1.4 | 0.001 | 0.018 | 1 |
| ATP2B1 | Plasma membrane calcium-transporting ATPase 1 | 1.4 | 0.042 | 0.065 | 1 |
| F3 | Tissue factor | 1.4 | 0.030 | 0.052 | 1 |
| RAP1B | Ras-related protein Rap-1b | 1.3 | 0.008 | 0.027 | 1, 2 |
| CDC42 | Cell division control protein 42 homolog | 1.3 | 0.003 | 0.019 | 1 |
| APOB | Apolipoprotein B-100 | 1.3 | 0.008 | 0.026 | 1 |
| GNA13 | Guanine nucleotide-binding protein subunit α-13 | 1.3 | 0.025 | 0.048 | 1, 2 |
| PFN1 | Profilin-1 | 1.2 | 0.015 | 0.036 | 1, 2 |
| GNA11 | Guanine nucleotide-binding protein subunit α-11 | 1.2 | 0.030 | 0.052 | 1, 2 |
| ITGA5 | Integrin α-5 | 1.2 | 0.027 | 0.050 | 1 |
| F2 | Prothrombin | 1.2 | 0.041 | 0.063 | 1, 2 |
| RHOA | Transforming protein RhoA | 1.2 | 0.053 | 0.076 | 1, 2 |
| GNAI1 | Guanine nucleotide-binding protein G(i) subunit α-1 | 1.4 | 0.121 | 0.125 | 1, 2 |
| EHD2 | EH domain-containing protein 2 | 1.4 | 0.275 | 0.211 | 1 |
| PLAUR | Urokinase plasminogen activator surface receptor | 1.2 | 0.169 | 0.154 | 1 |
| COL1A2 | Collagen α-2(I) chain | 1.2 | 0.761 | 0.356 | 1 |
| SERPINE1 | Plasminogen activator inhibitor 1 | 1.2 | 0.143 | 0.138 | 1 |
| CFL1 | Cofilin-1 OS = Homo sapiens GN = CFL1 PE = 1 SV = 3 |
1.2 | 0.092 | 0.104 | 1, 2 |
| F5 | Coagulation factor V | 1.2 | 0.187 | 0.165 | 1 |
| APOA1 | Apolipoprotein A-I | 1.2 | 0.139 | 0.137 | 1, 2 |
| AP2M1 | AP-2 complex subunit mu | 1.1 | 0.152 | 0.143 | 1, 2 |
| CAV1 | Caveolin-1 | 1.1 | 0.234 | 0.188 | 1 |
| ITGA2 | Integrin α-2 | 1.1 | 0.285 | 0.216 | 1 |
| STX4 | Syntaxin-4 | 1.1 | 0.671 | 0.340 | 1, 2 |
| CAP1 | Adenylyl cyclase-associated protein 1 | 1.1 | 0.473 | 0.281 | 1, 2 |
| YWHAZ | 14-3-3 protein zeta/delta | 1.1 | 0.614 | 0.323 | 1, 2 |
| FLNA | Filamin-A | 1.1 | 0.331 | 0.233 | 1, 2 |
| SERPINC1 | Antithrombin-III | 1.1 | 0.619 | 0.324 | 1 |
| HBB | Haemoglobin subunit β | 1.0 | 0.799 | 0.364 | 1 |
| WDR1 | WD repeat-containing protein 1 | 1.0 | 0.974 | 0.410 | 1, 2 |
| MAPK1 | Mitogen-activated protein kinase 1 | 1.0 | 0.927 | 0.397 | 1, 2 |
| CAPZA2 | F-actin-capping protein subunit α-2 | 1.0 | 0.716 | 0.349 | 1 |
| COL1A1 | Collagen α-1(I) chain | 0.9 | 0.799 | 0.364 | 1 |
| TLN1 | Talin-1 | 0.9 | 0.270 | 0.208 | 1, 2 |
| SERPINF2 | α-2-antiplasmin | 0.9 | 0.569 | 0.312 | 1 |
| PRKAR1A | cAMP-dependent protein kinase type I-α regulatory subunit | 0.9 | 0.250 | 0.197 | 1 |
| HSPA5 | 78 kDa glucose-regulated protein | 0.9 | 0.340 | 0.238 | 1, 2 |
| CAPZB | Isoform 2 of F-actin-capping protein subunit β | 0.9 | 0.153 | 0.143 | 1 |
| VCL | Vinculin | 0.8 | 0.095 | 0.105 | 1, 2 |
| EHD1 | EH domain-containing protein 1 | 0.8 | 0.403 | 0.265 | 1 |
| TF | Serotransferrin | 0.7 | 0.089 | 0.102 | 1, 2 |
| TUBA4A | Tubulin α-4A chain | 0.8 | 0.004 | 0.020 | 1, 2 |
| FN1 | Fibronectin | 0.7 | 0.003 | 0.019 | 1 |
Proteins were ordered according to the fold-change (FC; CSE-EVs/control-EVs). Significant q-values (<0.05) are printed in bold.