TABLE 2.

Peak ibuprofen plasma kinetics pre- and post-lumacaftor/ivacaftor initiation

Patient	Lumacaftor/ ivacaftor status	Age (years)	Dose (mg)	Weight (kg)	Weight- based dose (mg/kg)	Time to peak ibuprofen plasma concentration (minutes)	Peak ibuprofen plasma concentration (mcg/mL)	Absolute change in peak ibuprofen plasma concentrations (mcg/mL)	Relative change in peak ibuprofen plasma concentrations (%)
1	Pre	8.1	500	21.3	23.5	120	79	−20.0	−25.3
	Post	10.2	600	24.9	24.1	120	59
2	Pre	11.5	800	36.6	21.9	120	76	−15.0	−19.7
	Post	13.5	1000	46.6	21.5	120	61
3	Pre	8.8	800	31.8	25.2	120	86	−73.3	−85.2
	Post	13.0	1000	44.4	22.5	180	12.7
4	Pre	8.2	500	23.4	21.4	60	101	−67.0	−66.3
	Post	9.5	600	26.6	22.6	120	34
5	Pre	11.5	800	32.2	24.8	60	87	−37.0	−42.5
	Post	12.6	1000	43.0	23.3	60	50
6	Pre	10.9	1000	47.2	21.2	120	88	−20.0	−22.7
	Post	12.3	1400	58.6	23.9	60	68
7	Pre	13.5	1200	57.8	20.8	120	89	−40.0	−44.9
	Post	15.5	1400	66.2	21.1	120	49
8	Pre	8.2	600	24.3	24.7	60	90	−40.0	−44.4
	Post	13.4	1000	43.7	22.9	120	50
9	Pre	6.6	500	20.0	25.0	120	62	−15.0	−24.2
	Post	10	700	24.7	28.3	60	47
Average	Pre	9.7	744	32.7	23.2	100	84.2	−36.4	−41.7
	Post	12.2	967	42.5	23.0	107	47.9