Figure 5. Geographical differences in APOE4 frequency and ethnic risk mitigation.
A) Worldwide APOE4 allele frequency (For methods and references, see Supplementary text). B) APOE-related risk for Alzheimer’s disease (clinically defined) across all six APOE genotypes, for Caucasians (left), African-Americans (second from left), Hispanics (second from right), and Japanese (right) patient groups (Farrer et al., 1997). Figure panel B is a visual adaptation of data, with permission, from American Medical Association © Farrer, L. et al. JAMA. 278, 1349–1356 (1997).