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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Science. 2019 Feb 15;363(6428):eaar7785. doi: 10.1126/science.aar7785

Fig. 1. pks+ E. coli synthesize cyclopropane-containing metabolites that may alkylate DNA.

Fig. 1.

(A) pks genomic island. Open reading frames encoding nonribosomal peptide synthetase (NRPS) (purple), polyketide synthase (PKS) (brown), hybrid NRPS/PKS (blue), peptidase (ClbP) (green), aminomalonate synthesis and transfer (grey), and other (black) enzymes are highlighted. (B) Selected cyclopropane-containing candidate precolibactins isolated and structurally characterized from pks+ ΔclbP E. coli, including lactam, pyridone, and macrocyclic scaffolds. (C) Illudin S and (+)-duocarmycin A are DNA alkylating metabolites that contain a cyclopropane ring.