Table 2.

Pharmacokinetic parameters for a 200 mg tablet of BI 853520 administered under fed and fasted conditions

Parameter	Fed	Fasted	Adjusted GMR,  % (90% CI) [fed/fasted]
Patients, n	15	15	–
t max a	4 [1–24]	3 [1–6]	–
${\text{AUC}}_{0-t_{\text{z}}}$, nM·h	30,992c	33,518	92.46 (74.24–115.16)
AUC0–∞,obs, nM·h	39,219	39,949	98.17 (78.53–122.74)
Cmax, nM	1636	1873	87.34 (71.04–107.38)
t½, hb	18.0 (16.1)c	18.0 (22.6)	–

Unless otherwise specified, data are adjusted geometric mean

AUC_0–∞,obs observed area under the plasma concentration–time curve extrapolated from time zero to infinity, $AU{C}_{0-t_z}$ area under the plasma concentration–time curve from time zero to the last quantifiable concentration at t_z, C_max maximum plasma concentration, t_½ terminal half-life, t_max time to maximum plasma concentration, – not calculated

^aMedian [range]

^bGeometric mean [coefficient of variation (%)]

^cn = 14