Table 3.

Pharmacokinetic parameters of 200 mg BI 853520 administered as a tablet or liquid formulation

Parameter	Tablet	Liquid	Adjusted GMR,  % (90% CI) [tablet/liquid]
Patients, n	16	14	–
t max a	2 [1–6]	2 [1–6]	–
${\text{AUC}}_{0-t_{\text{z}}}$, nM·h	26,376	26,381	99.98 (92.28–108.33)
AUC0–∞,obs, nM·h	31,978	31,460	101.65 (93.57–110.42)
Cmax, nM	1721	1606	107.15 (98.79–116.22)
t½, hb	19.5 (16.4)	18.4 (22.7)	–

Unless otherwise specified, data are adjusted geometric mean

AUC_0–∞,obs observed area under the plasma concentration–time curve extrapolated from time zero to infinity, $AU{C}_{0-t_z}$ area under the plasma concentration–time curve from time zero to the last quantifiable concentration at t_z, C_max maximum plasma concentration, t_½ terminal half-life, t_max time to maximum plasma concentration, - indicates not calculated

^aMedian [range]

^bGeometric mean [coefficient of variation (%)]