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. 2018 Dec 3;160(3):712–723. doi: 10.1097/j.pain.0000000000001450

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — Effects of EA on CFA-induced hyperalgesia in ICA69-WT and ICA69-KO mice. (A) An increase in paw withdrawal frequency of the KO-CFA+EA group compared with the WT-CFA+EA group on the ipsilateral side (n = 13; *P < 0.05); this effect was obvious at day 1, day 3, and day 5 (n = 13; *P < 0.05, **P < 0.01). There was no difference between the KO-CFA+EA and the KO-CFA group (n = 13; P > 0.05), and there was no difference between KO-CFA and WT-CFA groups (n = 13; P > 0.05). (B) There was no difference among the 6 groups on the contralateral side (n = 13; P > 0.05). (C) Reduction in paw withdrawal latency of the KO-CFA+EA group compared with the WT-CFA+EA group on the ipsilateral side (n = 13; *P < 0.05); this effect was particularly obvious at day 3 and day 5 (n = 13; *P < 0.05, **P < 0.01). There was no difference between the KO-CFA+EA group and the KO-CFA group (n = 13; P > 0.05), and there was no difference between KO-CFA and WT-CFA groups (n = 13; P > 0.05). (D) No difference among the 6 groups was detected on the contralateral side (n = 13; P > 0.05). CFA, complete Freund adjuvant; EA, electroacupuncture; KO, knockout; WT, wild-type.