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. 2018 Dec 3;160(3):712–723. doi: 10.1097/j.pain.0000000000001450

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 4. — Effects of EA on CFA-induced hyperalgesia and the protein levels of PICK1, ICA69, GluR2-p, and GluR2 in PICK1-WT and PICK1-KO mice. (A) Western blot bands of PICK1 and quantitative analyses of PICK1 on both sides in PICK1-WT mice. (B) Reduction in paw withdrawal frequency of the KO-CFA group compared with the WT-CFA group on the ipsilateral side (n = 13; *P < 0.05); the effect was particularly obvious at day 0, day 1, day 3, day 5, and day 7 (n = 13; *P < 0.05, **P < 0.01). There was no difference between KO-CFA+EA and KO-CFA groups (n = 13; P > 0.05), and there was no difference between KO-CFA and WT-CFA+EA groups (n = 13; P > 0.05). (C) No difference among the 6 groups on the contralateral side (n = 13; P > 0.05). (D) Increase in paw withdrawal latency of the KO-CFA group compared with the WT-CFA group on the ipsilateral side (n = 13; *P < 0.05); the effect was particularly obvious at day 0 and day 1 (n = 13; *P < 0.05). There was no difference between KO-CFA+EA and KO-CFA groups (n = 13; P > 0.05), and there was no difference between KO-CFA and WT-CFA+EA groups (n = 13; P > 0.05). (E) There was no difference among the 6 groups on the contralateral side (n = 13; P > 0.05). (F) Representative Western blot bands of PICK1, ICA69, GluR2-p, and GluR2 in PICK1-WT and PICK1-KO mice, and quantitative analyses of these bands (n = 3, group values are indicated by mean ± SEM; **P < 0.01). CFA, complete Freund adjuvant; EA, electroacupuncture; KO, knockout; WT, wild-type.