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. 2018 Dec 3;160(3):712–723. doi: 10.1097/j.pain.0000000000001450

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 5. — Effects of EA on the formation of endogenous ICA69-PICK1 and PICK1-GluR2 complexes. (A) Endogenous protein was collected from SDH. Representative Western blot bands of ICA69, GluR2, and PICK1 in WT mice by co-IP. (B and C) Quantitative analyses of ICA69 and GluR2 to evaluate the ability of binding to PICK1. Increased ICA69 and reduced GluR2 interactions were observed with PICK1 in the CFA+EA group (n = 3, group values are indicated by mean ± SEM; **P < 0.01). (D) Electroacupuncture caused an increase in colocalization between endogenous ICA69 (red) and PICK1 (green) on the ipsilateral side in SDH. CFA, complete Freund adjuvant; EA, electroacupuncture; SDH, spinal dorsal horn; WT, wild-type.