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. Author manuscript; available in PMC: 2019 Mar 8.
Published in final edited form as: Sci Immunol. 2018 Sep 28;3(27):eaau2125. doi: 10.1126/sciimmunol.aau2125

Fig. 3. Probacterial effect of USP18 is independent of its isopeptidase activity or cytokine production.

Fig. 3.

(A) WT and Usp18C61A/C61A mice were infected with 4000 CFU L.m. After 4 days, titers of bacteria were measured in the indicated organs (n = 6 to 7). (B) WT and Ube1L−/− mice were infected with 4000 CFU L.m. After 4 days, titers of bacteria were measured in the indicated organs (n = 7 to 8). (C) Usp18fl/fl CD11c-Cre mice and littermate controls were infected with 4000 CFU L.m. IFN-γ and TNF-α production were measured in the serum at the indicated time points (n = 4 to 6). Statistical significance was determined by Student’s t test (A and B) and two-way ANOVA (C). n.s., not significant; *P < 0.05; **P < 0.01. Data are pooled from two independent experiments (A to C).