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. Author manuscript; available in PMC: 2019 Mar 8.
Published in final edited form as: Pharmacol Biochem Behav. 2017 Sep 15;161:47–52. doi: 10.1016/j.pbb.2017.08.013

Figure 1. Sucrose preference test during spontaneous nicotine withdrawal in C57BL/6J mice.

Figure 1.

C57BL/6J male mice were exposed to two sipper tubes, one containing normal drinking water and the other containing a 2% sucrose solution, for 24 hrs per day. Sucrose preference was determined as the percentage of 2% sucrose volume consumed over the total fluid intake volume. Mice were chronically exposed to nicotine (12 and 24 mg/kg/day) via osmotic minipumps then the sucrose preference was measured for 9 consecutive days after removal of minipumps. Sucrose preference deficit was observed in nicotine withdrawn groups when compared to saline group. Also, there was a dose dependent effect in nicotine treated groups at days 1, 2 and 4 during nicotine withdrawal. Each point represents the mean ± S.E.M. of 11 mice per group. *Denotes P < 0.05 from saline group; # Denotes P < 0.05 from nicotine 12 mg/kg/day treated-group.