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. Author manuscript; available in PMC: 2019 Mar 8.
Published in final edited form as: Pharmacol Biochem Behav. 2017 Sep 15;161:47–52. doi: 10.1016/j.pbb.2017.08.013

Figure 3. Time course of time spent in the light side of nicotine-dependent mice in the LDB test.

Figure 3.

Mice were chronically infused with saline or nicotine (12 or 24 mg/kg/day) for 14 days. On day 15 mice underwent spontaneous nicotine withdrawal and the LDB test was performed at days 1, 2 and 5 after removal of minipumps. Each point represents the mean ± S.E.M. of 10 mice per group. *Denotes P < 0.05 from vehicle control, # Denotes from 12 mg/kg/day nicotine withdrawn group.