Fig. 1.

Exploratory activity in the open field test. (A-F) Wild-type and mGlu2-KO mice were placed in the locomotor chamber, and allowed to habituate for 5 min. After habituation, horizontal activity (n = 22–23) and time spent in the center of the arena (n = 5–6) was measured for 85 min. Horizontal activity (A-C) and the proportion of time spent in the center of the arena (D-F) are shown. Time courses (A,D) and total counts from t = 5 to t = 30 min (B,E) and from t = 35 to t = 85 min (C,F) are shown for each measurement. *P < 0.05, **P < 0.01, ***P < 0.001, Bonferroni’s post hoc test of two-way ANOVA (A,D) or unpaired Student’s t-test (B,C,E,F). Data are means ± SEM, n.s., not significant.