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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Psychopharmacology (Berl). 2018 Sep 12;235(11):3149–3165. doi: 10.1007/s00213-018-5015-4

Fig. 9.

Fig. 9.

Virally mediated over-expression of mGlu2, but not mGlu2DTM4, in the frontal cortex of mGlu2-KO mice rescues the effect of clozapine on MK801-induced hyperlocomotor activity. (A-E) HSV-GFP, HSV-mGlu2 or HSV-mGlu2DTM4 were injected into the frontal cortex of mGlu2-KO mice. Animals were placed in the locomotor chamber and allowed to habituate for 90 min. After habituation, mice were injected with clozapine (1.5 mg/kg) or vehicle followed by MK801 (0.5 mg/kg), and locomotor activity was measured for another 120 min (n = 7–8). (A-C) The panel depicts the time course of MK801-induced locomotion in 5 min blocks. Time of injection is indicated by arrow. (D,E) Data summary of the total MK801-induced locomotion as a summation of horizontal activity from t = 20 to t = 80 min (D) and from t = 85 to t = 120 min (E). *P < 0.05, **P < 0.01, ***P < 0.001, Bonferroni’s post hoc test of two-way ANOVA. Data are means ± SEM, n.s., not significant.