. Author manuscript; available in PMC: 2020 Mar 8.

Published in final edited form as: ACS Infect Dis. 2019 Jan 23;5(3):365–371. doi: 10.1021/acsinfecdis.8b00253

Table 1 -.

Swiss male mice infected with bloodstream trypomastigotes of Colombiana strain (n=5) and submitted to mono (VFV, VNI and Bz) and co-administration therapy (Bz and VFV). VNI and VFV were diluted in 10 % DMSO plus 5 % Gum Arabic.

	Parasitemia peak (mean ± SD number parx10⁴/mL)	% Parasitemia suppression	% Animal survival	Natural relapse after the therapy
Bz 60 days	0 ± 0	100	100	5 out of 5 mice
VNI 60 days	0.2 ± 0.4	99.9	100	3 out of 5 mice
VFV 60 days	0.2 ± 0.4	99.9	100	5 out of 5 mice
Bz+VFV (simultaneous)^**	1.4 ± 3.1	99.9	100	3 out of 5 mice

^**

Simultaneous therapy: 60 days of Bz + VFV (once a day)