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. Author manuscript; available in PMC: 2020 Mar 8.
Published in final edited form as: ACS Infect Dis. 2019 Jan 23;5(3):365–371. doi: 10.1021/acsinfecdis.8b00253

Table 4 -.

Swiss male mice infected with bloodstream trypomastigotes of Colombiana strain (n=10) and submitted to mono (VFV and Bz) and co-administration therapy (Bz and VFV). VFV was diluted using 10 % DMSO + 5 % arabic gum + 3 % Tween 80 - (DGAT) and Bz dissolved in water + 3 % Tween 80.

Parasitemia peak (mean ± SD number parx104/mL) % Parasitemia suppression % Animal survival Natural relapse after the therapy % Blood parasite clearence (negative qPCR)
Bz 60 days 0 ± 0 100 100 6 out of 10 mice 30
VFV 60 days 5.7 ± 5.1 99.8 100 5 out of 10 mice 0
Bz+VFV 0 ± 0 100 100 2 out of 10 mice 70*
*

One out of the 8 negative samples was lost during the qPCR procedure