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. Author manuscript; available in PMC: 2019 Aug 9.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2018 Feb 9;1860(9):1818–1825. doi: 10.1016/j.bbamem.2018.02.005

Fig. 4.

Fig. 4.

(a-c) Snapshots of hIAPP protofibril at membrane interface in a representative MD run of each system. The hydrophilic, hydrophobic, Lys1, Arg11, and positively charged His18 residues are colored in cyan, gray, red, orange, and yellow, respectively; DPPG and DPPC lipids are denoted in silver and green, with phosphorus atoms in spheres. (d-f) Average z-position of each residue of hIAPP protofibirl at bilayer surface and water density profile along the membrane normal for hIAPP-DPPG(N) (d), hIAPP-DPPG(A) (e) and hIAPP-DPPC/DPPG(N) (f) systems. Average z-positions of phosphorus atoms in upper and lower leaflets are denoted by green dashed line.