Table 2.

Hazard ratios (with 95% CIs) for variables evaluated as potential predictors of all-cause mortality in the study population.

Factors	n (%)	Unadjusted			Adjusted
		HR	95% CI	P-value	HR	95% CI	P-value
Sex
Male	5,714 (63.8)	1.000	Reference	Reference	1.000	Reference	Reference
Female	3,240 (36.2)	0.898	0.787–1.025	0.114	0.772	0.438–1.378	0.376
Age
1-year increase	8,954 (100)	1.081	1.073–1.087	<0.0001	1.113	1.078–1.149	<0.0001
PD duration (years)
<2	3,507 (39.2)	1.000	Reference	Reference	1.000	Reference	Reference
≥2 <4	2,344 (26.2)	1.170	0.978–1.399	0.086	1.374	0.966–1.953	0.076
≥4 <6	1,422 (15.9)	1.432	1.165–1.762	0.001	1.627	1.173–2.256	0.004
≥6 <8	761 (8.5)	1.676	1.233–2.278	0.001	1.720	1.041–2.841	0.045
≥8 <10	414 (4.6)	1.545	1.093–2.183	0.013	2.211	1.377–3.549	0.002
≥10	506 (5.6)	1.506	1.113–2.036	0.007	2.979	1.687–5.259	0.002
Diabetes
No	5,635 (62.9)	1.000	Reference	Reference	1.000	Reference	Reference
Yes	3,319 (37.1)	1.500	1.318–1.708	<0.0001	1.648	1.097–2.474	0.016
Comorbid CVD
No	7,399 (84.9)	1.000	Reference	Reference	1.000	Reference	Reference
Yes	1,313 (15.1)	2.861	2.464–3.322	<0.0001	1.367	1.055–1.771	0.017
Use of antihypertensive medication
No	1,264 (20.8)	1.000	Reference	Reference	1.000	Reference	Reference
Yes	4,802 (79.2)	0.509	0.422–0.615	<0.0001	0.667	0.501–0.889	0.005
Residual renal function
Non-anuric	3,479 (77.2)	1.000	Reference	Reference	1.000	Reference	Reference
Anuric	1,026 (22.8)	1.677	1.330–2.114	<0.0001	1.257	0.785–1.984	0.335
Total Kt/V
<1.1	286 (8.7)	2.313	1.481–3.614	0.001	2.431	0.925–6.386	0.071
≥1.1 <1.4	326 (9.9)	1.392	0.806–2.405	0.235	1.162	0.419–3.222	0.772
≥1.4 <1.7	682 (20.7)	1.000	Reference	Reference	1.000	Reference	Reference
≥1.7 <2.0	853 (25.9)	1.159	0.784–1.713	0.457	0.792	0.350–1.791	0.576
≥2.0	1,144 (34.8)	0.832	0.563–1.230	0.358	0.614	0.262–1.437	0.262
Use of 2.5% dialysate
No	3,422 (62.5)	1.000	Reference	Reference	1.000	Reference	Reference
Yes	2,056 (37.5)	1.502	1.267–1.779	<0.0001	2.551	1.433–4.539	0.001
Use of icodextrin dialysate
No	3,241 (59.2)	1.000	Reference	Reference	1.000	Reference	Reference
Yes	2,237 (40.8)	1.307	1.102–1.548	0.002	0.968	0.641–1.445	0.876
PD + HD combination therapy
No	7,275 (81.2)	1.000	Reference	Reference	1.000	Reference	Reference
Yes	1,679 (18.8)	0.556	0.438–0.703	<0.0001	0.595	0.413–0.858	0.005
Hemoglobin
1-g/dL increase	6,130 (68.5)	0.773	0.726–0.823	<0.0001	0.925	0.844–1.014	0.098
C-reactive protein
1-mg/dL increase	5,344 (59.7)	1.571	1.467–1.682	<0.0001	1.217	1.073–1.381	0.002
Body mass index
1-kg/m2 increase	5,330 (59.5)	0.910	0.885–0.935	<0.0001	0.906	0.847–0.969	0.004
Serum albumin
1-g/dL increase	6,092 (68.0)	0.217	0.190–0.247	<0.0001	0.363	0.234–0.562	<0.0001
Non-HDL cholesterol
1-mg/dL increase	3,658 (40.9)	0.996	0.993–0.999	0.042	0.995	0.989–1.001	0.097
HDL cholesterol
1-mg/dL increase	4,264 (47.6)	0.982	0.976–0.989	<0.0001	0.981	0.968–0.995	0.008
Calcium (mg/dL)
1-mg/dL increase	6,175 (69.0)	0.748	0.685–0.819	<0.0001	1.145	0.877–1.493	0.317
Phosphate (mg/dL)
1-mg/dL increase	7,340 (82.0)	0.871	0.818–0.925	<0.0001	1.231	1.046–1.450	0.012

CI, confidence interval; CVD, cardiovascular disease; HD, hemodialysis; HDL, high-density lipoprotein; HR, hazard ratio; PD, peritoneal dialysis.