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. 2019 Mar 8;9:4014. doi: 10.1038/s41598-019-40514-9

Table 2.

Significant changes of CC chemokines among different histological types of BrCa.

Data set Tissue Type (No. of Cases) CCL5 CCL7 CCL11 CCL17 CCL20 CCL22 CCL25
FC p FC p FC p FC p FC p FC p FC p
Bittner Ductal (n = 260) 1.4 0.02 1.5 0.002 1.4 0.008 — — 1.5 0.008 1.1 0.3 −1.1 0.7
Lobular (n = 38) −1.1 0.7 −1.6 1 1.3 0.25 — — −1.6 1 −1.2 1 −1.1 0.8
Boersma78 Ductal (n = 83) 1.1 0.4 1.2 0.014 1.3 0.003 1 0.3 1.1 0.3 −1.2 0.7 1.3 0.008
Lobular (n = 10) 1.1 0.4 −1.2 1 −1.3 1 −1 0.7 −1.1 0.7 1.2 0.2 −1.3 1
Curtis23 Ductal (n = 1556) 1 0.36 1 0.002 1 0.02 — — 1 1.3e−4 1.1 2.3e−9 1 0.4
Medullary (n = 32) 3.3 1e −7 1.3 0.007 1 0.2 — — 1.4 0.002 1.2 0.02 1.2 4.1e−4
Lobular (n = 148) 1.1 0.14 −1.1 1 −1 1 — — −1.1 1 −1.1 1 −1 1
Desmedt79 Ductal (n = 158) 1.5 0.06 1.3 0.09 1.1 0.3 — — 1.2 0.2 1.1 0.3 1 0.4
Lobular (n = 13) −1.2 0.9 −1.4 1 −1.1 0.8 — — −1.2 0.7 −1.3 0.9 −1 0.6
Esserman80 Ductal (n = 105) 1.1 0.4 1.9 0.04 1.3 0.05 1.1 0.4 −1.1 0.7 −1.1 0.7 1 0.4
Lobular (n = 8) 1.1 0.4 −2.3 1 −1.2 0.9 −1.2 00.8 1.2 0.3 1.1 0.3 1 0.4
Ginester24 Ductal (n = 45) −3.8 1 −1.3 0.8 −1.3 0.74 1 0.23 −3.2 1 1.2 0.84 −1.1 0.7
Medullary (n = 5) 8.5 0.004 1.8 0.07 1.8 0.13 1 0.335 6 0.012 1.2 0.11 1.2 0.08
Lu26 Ductal (n = 95) 1.2 0.13 1.4 0.04 1.1 0.2 — — 3.5 9.9e −5 1 0.5 −1 0.5
Lobular (n = 19) −1.2 0.8 −1.3 0.9 −1.1 0.8 — — −2.7 1 1.3 0.2 −1 0.5
MA281 Ductal (n = 32) −1.6 0.9 1 0.3 −1.1 0.8 1.1 0.14 −1.1 0.6 1.1 0.4 −1.1 0.7
Lobular (n = 3) 3.7 0.06 −1 0.8 −1.1 0.7 −1 0.7 −1.1 0.8 −1.1 0.6 −1 0.6
MA381 Ductal (n = 51) −1.2 0.7 1 0.4 −1.2 0.8 1.1 0.3 −1.1 0.6 −1.2 0.9 1 0.4
Lobular (n = 3) 1.8 0.2 1 0.3 1.4 0.04 1.3 0.2 −1.1 0.6 1.9 0.1 1.1 0.4
MA482 Ductal (n = 18) −1 0.61 — — −1.1 0.8 −1.1 1 −1.2 0.6 −1.2 1 −1 0.5
Ductal in situ (n = 20) 1.9 0.04 — — 1.1 0.2 1.1 0.04 1.2 0.4 1.2 0.07 1 0.5
Perou27 Ductal (n = 54) 1.1 0.4 −1 0.5 1 0.4 — — — — — — −1.7 1
Lobular (n = 4) −1 0.7 1 0.5 −1 0.6 — — — — — — 1.7 0.03
Pollack83 Ductal (n = 105) −1.1 0.63 1.6 0.1 1.3 0.3 — — — — — — −2.5 0.8
Lobular (n = 8) 1.1 0.4 −1.6 0.9 −1.3 0.8 — — — — — — 2.5 0.2
Radvanyi25 Ductal (n = 26) — — — — 2.8 1e−4 1.3 0.3 1.7 0.4 1.3 0.2 −1.3 0.7
Lobular (n = 4) — — — — −1.7 0.9 1.5 0.2 −1.1 0.8 1.9 0.04 1.1 0.3
Ductal in situ (n = 2) — — — — −2.8 1 −1.3 0.7 −1.7 0.6 1.8 0.1 1.3 0.3
Schuetz84 Ductal (n = 5) 1.3 0.25 — — 1.2 0.03 −1.1 0.9 −1.4 1 −1.1 0.9 1 0.4
Ductal in situ (n = 5) −1.3 0.73 — — −1.2 1 1.1 0.15 1.4 0.02 1.1 0.15 −1 0.6
Sorlie85 Ductal (n = 66) 1.5 0.1 1.2 0.2 1.5 0.08 — — — — — — −2 0.9
Lobular (n = 5) −1.2 0.6 −1.2 0.8 −1.5 0.83 — — — — — — 2.8 0.2
Sorlie286 Ductal (n = 132) 1.2 0.3 — — 1.4 0.05 — — — — — — — —
Lobular (n = 11) −1 0.5 — — −1.5 0.92 — — — — — — — —
Tabchy87 Ductal (n = 163) −1.3 0.9 1.1 0.12 −1 0.8 −1 0.81 1.2 0.2 −1.1 0.9 −1.1 0.9
Lobular (n = 7) 1.5 0.11 −1 0.8 1.1 0.09 1.1 0.3 −1.2 0.7 1.1 0.1 1.2 0.1
TCGA Ductal (n = 392) 1.7 0.2 2.1 2.5e−6 −2.4 0.8 1.5 0.2 −1.4 0.7 −1.1 0.6 1.2 0.2
Lobular (n = 36) 1.4 0.04 −1.8 1 −1 0.7 1.3 0.03 −1.1 0.8 1 0.4 −1 0.5
Ductal in situ (n = 3) — — — — 2.1 0.1 −1.3 0.7 2 0.2 2.6 0.1 1.4 0.02
Turashvili88 Ductal (n = 5) 1.5 0.3 −1.6 0.8 2 0.2 −1 0.5 −1.1 0.6 1.1 0.4 −1 0.5
Lobular (n = 5) −1.1 0.5 1.6 0.2 −2 0.8 1 0.5 1.1 0.4 −1.1 0.5 1 0.5
Zhao89 Ductal (n = 39) 1.3 0.01 −1.2 0.81 −1.1 0.6 — — — — 1 0.3 — —
Lobular (n = 21) −1.1 0.7 1.2 0.2 1.1 0.4 — — — — −1 0.7 — —

Histological types of 7 CC chemokines over-expressed in BrCa compared to normal tissues were determined utilizing all datasets available in ONCOMINE.

Bold represents significant RNA expression with a cut off of: fold change (FC) ≥ 1.4 and p-value ≤ 0.04 using t-test.