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. 2019 Mar 8;10:1150. doi: 10.1038/s41467-019-09117-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Manhattan plot showing the P values for the meta-analysis genome-wide association study. Each SNP was tested for association by logistic regression using an additive regression model; the interrupted line indicates the threshold for genome-wide significance (P = 5 × 10⁻⁸); the y axis has been collapsed for better illustration of all genomic signals; the continuous line represents the threshold for suggestive significance (P = 1 × 10⁻⁵); N = 5161 biologically independent subjects (N_cases = 1044 and N_controls = 4145)