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. 2019 Mar 8;10:1150. doi: 10.1038/s41467-019-09117-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Regional plot at locus 2p22.2 and CYP1B1 enzyme structure. a Regional plot of lead signal at locus 2p22.2 demonstrating the lead causal variant (rs1800440); the blue lines shows the fine-scale recombination rates (right y axis) estimated from individuals in the 1000 Genomes population; genes are highlighted with horizontal lines; the x axis shows the chromosomal position in Mb; variants within the 95% credible set are highlighted in red (N = 1, posterior probability = 0.98); b CYP1B1 enzyme structure drawn via the SWISS-MODEL repository with the site affected by the residue change from Asparagine (N) to Serine (S) at position 453 magnified (https://swissmodel.expasy.org/repository)