Table 1.
Summary of the effects of HBAs and HBDs, on the two studied cell lines, after 72 h of exposure.
| Chemical compounds | Cell line | Effect trend | IC50 ± SD (μg.mL−1) | LOEC (μg.mL−1) | |
|---|---|---|---|---|---|
| HBA | [Chol]Cl | HaCaT MNT-1 |
Increase (slightly) Increase (slightly) |
— — |
50 200 |
| [N1111]Cl | HaCaT MNT-1 |
No effect No effect |
— — |
50 — |
|
| [N4444]Cl | HaCaT MNT-1 |
Toxic effect Toxic effect |
220.8 ± 6.2 316.1 ± 25.7 |
200 50 |
|
| HBD | Butanoic acid | HaCaT MNT-1 |
Toxic effect Toxic effect |
309.2 ± 11.6 274.8 ± 5.0 |
— — |
| Hexanoic acid | HaCaT MNT-1 |
Increase Toxic (slightly) |
— — |
50 50 |
|
| Ethylene glycol | HaCaT MNT-1 |
Increase Increase |
— — |
50 50 |
|
| 1-Propanol | HaCaT MNT-1 |
No effect Increase |
— — |
— 50 |
|
| Urea | HaCaT MNT-1 |
Increase Increase |
— — |
100 50 |
The effect trend concerns the effect of the chemicals in cell viability. Inhibitory concentration values (IC50) and Lowest Observed Effect Concentration (LOEC) (Dunnett test following one-way ANOVA; p < 0.05; see Supplementary Table S1 for the ANOVA summary) are also presented.