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. 2019 Mar 8;9:3913. doi: 10.1038/s41598-019-40361-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miRNA organ-enriched expression. (A,B) Frequency plot of OEI (organ enrichment index) values for all stickleback and zebrafish miRNAs expressed at more than 5 RPM across the entire dataset. Grey bars represent miRNAs that were also enriched in brain, heart, testis, ovary, or in both gonads, and white bars represent miRNAs that were not found to be enriched in a specific organ. (C–N) Average organ expression of evolutionarily-conserved, organ-enriched miRNAs that have an OEI > 0.85. Expression levels are given in RPM (Reads per Million) with associated standard deviations for the four organs studied in both stickleback (grey bars) and zebrafish (black bars).