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. 2019 Mar 8;9:3931. doi: 10.1038/s41598-019-40571-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The impact of germline cancer-associated variants on clinical outcome. (A) Germline cancer-associated variants identified in 55 gynecological and 104 CRC patients. Variants of cancer-associated genes in the ClinVar database were selected for analysis. After filtering out in-house control, 16 germline cancer-associated variants were detected in 23 patients. (B) The relationship between germline cancer-associated variants and cancer family history tested by Chi-square test. (C) The Kaplan-Meier curves of disease-free survival in CRC patients with and without germline cancer-associated variants. (D) The relationship between germline cancer-associated variants and drug response ERCC1 gene tested by Chi-square test.