Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 8;9:3947. doi: 10.1038/s41598-019-40418-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Superpositions of LpxA and LpxD. (a) The structure of LpxA with the bound product, UDP-3-O-(R-hydroxymyristoyl)-GlcNAc (PDB ID: 2QIA). LpxA is shown in grey and UDP-3-O-(R-hydroxymyristoyl)-GlcNAc is shown in pink. (b) LpxA-peptide CR20 superposed with the product bound structure of LpxA. (c) A close-up view to the product binding site. Peptide CR20 overlaps with UDP-3-O-(R-hydroxymyristoyl)-GlcNAc product. (d) The structure of LpxD in complex with the intact R-3-hydroxymyristoy-ACP (PDB ID: 4IHF). LpxD is shown in orange. ACP and the pantetheine arm are shown in cyan and magenta, respectively. (e) LpxA-peptide CR20 superposed with LpxD and intact R-3-hydroxymyristoy-ACP. (f) A close-up view to the acyl-ACP binding site. Peptide CR20 occludes the binding site of acyl-ACP at the pantetheine arm.