Skip to main content
. 2019 Mar 8;9:4007. doi: 10.1038/s41598-018-38321-9

Figure 3.

Figure 3

Effects of VWR on hepatic lipid metabolism and steatosis in HFD-fed mice. (A) Absolute liver weight, (B) liver triglyceride content, (C) representative liver histology by H&E staining (scale bar: 200 µm) and NAFLD activity score (NAS), and (D) relative mRNA expression of key regulators of hepatic lipid metabolism determined by qRT-PCR in VWR and SED mice after 12 weeks of dietary feeding. Data represent means ± SEM of (A) n = 7 VWR/CD, n = 8 VWR/HFD, n = 11 SED/CD, n = 20 SED/HFD, (B) n = 5 mice/group, (C) n = 7 VWR/CD, n = 8 VWR/HFD, n = 4 SED/CD, n = 8 SED/HFD, (D) n = 7 VWR/CD, n = 8 VWR/HFD, n = 5 SED/CD and n = 5 SED/HFD mice. *p < 0.05, **p < 0.01, ***p < 0.001 for CD vs. HFD and $p < 0.05, $$p < 0.01 for SED vs. VWR using Mann-Whitney U test (A,C) or two-tailed Student’s t-test (D).