. 2019 Mar 8;9:3979. doi: 10.1038/s41598-019-40482-0

Table 2.

Association between rs4828038 TNMD and anthropometric, biochemical, and inflammation characteristics (mean (SD)) in children.

Phenotype	Genotypes						Β (95%CI)	P	FDR adjusted P	Β_BMI (95%CI)	P _BMI	FDR adjusted P _BMI
Phenotype	T/T	n_T/T	T/C	n_T/C	C/C	n_C/C	Β (95%CI)	P	FDR adjusted P	Β_BMI (95%CI)	P _BMI	FDR adjusted P _BMI
Waist circumference (cm)
Females	75.68 (15.11)	124	77.13 (16.68)	168	77.15 (15.13)	168	−0.42 (−2.05, 1.04)	0.611^a	0.694	−1.22 (−2.06, −0.38)	0.005^a	0.024
Males	80.9 (17.4)	157	NA	0	77.04 (17.3)	220	3.76 (0.55, 6.98)	0.022^a	0.088	−0.1 (−1.54, 1.35)	0.897^a	0.962
Waist to Height Ratio
Females	0.526 (0.09)	109	0.54 (0.10)	151	0.53 (0.09)	142	−0.002 (−0.01, 0.009)	0.701^a	0.876	−0.01 (−0.01, 0.001)	0.030^a	0.172
Males	0.54 (0.10)	130	NA	0	0.53 (0.10)	194	0.015 (−0.007, 0.04)	0.183^a	0.735	−0.002 (−0.01, 0.01)	0.678^a	0.753
Systolic BP (mmHg)
Females	104.8 (14.43)	108	106.9 (12.73)	148	104.9 (13.81)	136	0.006 (−1.65, 1.66)	0.995^b	0.995	−0.46 (−1.95, 1.03)	0.542^b	0.995
Males	107.7 (15.06)	131	NA	0	105.9 (16.31)	193	1.01 (−2.15, 4.17)	0.531^b	0.995	0.07 (−2.91, 3.05)	0.963^b	0.995
Diastolic BP (mm Hg)
Females	62.82 (11.99)	108	65.17 (10.46)	148	65.46 (10.77)	136	−1.3 (−2.68. 0.09)	0.067^b	0.332	−1.60 (−2.91, −0.30)	0.016^b	0.102
Males	65.55 (11.31)	131	NA	0	63.82 (10.49)	193	1.53 (−0.82, 3.88)	0.204^b	0.446	0.96 (−1.32, 3.23)	0.410^b	0.708
Glucose (mg/dl)
Females	84.7 (7.93)	132	83.64 (6.89)	170	84.37 (7.02)	172	0.16 (−0.66, 0.97)	0.707^a	0.980	0.18 (−0.62, 0.99)	0.658^a	0.906
Males	85.9 (8.45)	171	NA	0	83.71 (8.43)	235	2.22 (0.57, 3.87)	0.009^a	0.049	2.21 (0.55, 3.88)	0.009^a	0.054
Insulin (mU/dl)
Females	12.85 (10.15)	131	13.5 (9.54)	164	11.63 (7.10)	167	0.81 (−0.14, 1.76)	0.094^a	0.196	0.72 (−0.15, 1.59)	0.104^a	0.443
Males	10.86 (7.67)	166	NA	0	9.50 (7.56)	224	1.39 (−0.02, 2.79)	0.053^a	0.196	0.74 (−0.55, 2.02)	0.261^a	0.443
HOMA-IR
Females	2.76 (2.36)	131	2.82 (2.04)	163	2.44 (1.55)	166	0.2 (−0.01, 0.41)	0.064^a	0.186	0.18 (−0.02, 0.38)	0.075^a	0.386
Males	2.34 (1.79)	165	NA	0	2.02 (1.72)	224	0.33 (0.009, 0.66)	0.044^a	0.186	0.19 (−0.11, 0.50)	0.207^a	0.386
QUICKI
Females	0.35 (0.05)	131	0.34 (0.04)	163	0.35 (0.04)	165	0.0001 (−0.004, 0.004)	0.953^a	0.952	0.0005 (−0.003, 0.004)	0.787^a	0.810
Males	0.35 (0.04)	165	NA	0	0.37 (0.05)	224	−0.01 (−0.02, −0.003)	0.006^a	0.038	−0.008 (−0.02, −0.0004)	0.039^a	0.232
TAG (mg/dl)
Females	72.57 (36.18)	132	71.58 (32.59)	170	67.1 (27.12)	172	2.86 (−0.74, 6.46)	0.120^a	0.615	2.63 (−0.87, 6.13)	0.142^a	0.878
Males	65.53 (35.37)	172	NA	0	64.32 (35.51)	234	1.35 (−5.59, 8.29)	0.703^a	0.915	−1.00 (−7.74, 5.73)	0.771^a	0.905
HDL-c (mg/dl)
Females	52.32 (14.03)	130	51.95 (13.77)	168	53.39 (13.69)	171	−0.6 (−2.17, 0.96)	0.451^a	0.683	−0.35 (−1.76, 1.06)	0.625^a	0.960
Males	55.25 (15.1)	169	NA	0	56.69 (16.53)	231	−1.53 (−4.67, 1.60)	0.338^a	0.683	0.20 (−2.64, 3.04)	0.892^a	0.960
IL-6 (ng/l)
Females	3.86 (7.22)	106	2.78 (4.51)	152	2.21 (3.83)	151	0.80 (0.17, 1.44)	0.014^a	0.047	0.75 (0.12, 1.38)	0.021^a	0.073
Males	3.25 (6.29)	142	NA	0	3.53 (5.80)	205	−0.30 (−1.59, 0.98)	0.642^a	0.818	−0.38 (−1.68, 0.92)	0.568^a	0.727

BMI, body mass index; BP, blood pressure; HOMA-IR, homeostasis model assessment for insulin resistance; QUICKI, quantitative insulin sensitivity check index; TAG, triglycerides; HDL-C, high-density lipoprotein cholesterol; IL, interleukin; MAF, minor allele frequency; β_BMI, Beta obtained under an additive model adjusted for BMI; P-value_BMI, P (P value) obtained under an additive model adjusted for BMI; CI, confidence interval; NA, not applicable. Linear regression analyses stratified by sex were performed under an additive model assuming TNMD locus escapes from the X-chromosome inactivation process. That is, while the female genotypes were coded 0, 1, or 2 according to 0, 1, or 2 TNMD SNP alleles, the genotypes for males were coded 0 or 1 according to 0 or 1 alleles. ^aAdjusted for age. ^bAdjusted for age and height.