Table 2.
Potential novel regulators of differentiation in chromaffin cells.
| Gene symbol | Gene name | Fold Change | Average CPM | FDR | |
|---|---|---|---|---|---|
| Adrenal Chromaffin Cells | Neuroblasts | ||||
| Elf3 | E74-like factor 3 | 129.61 | 70.21 | 0.53 | 2.91e-40 |
| Acvrl1 | Activin A receptor, type II-like 1 | 113.65 | 89.09 | 0.76 | 6.47e-43 |
| Gipr | Gastric inhibitory polypeptide receptor | 110.20 | 148.09 | 1.29 | 1.77e-56 |
| Casr | Calcium-sensing receptor | 77.26 | 79.92 | 0.98 | 1.88e-27 |
| Foxq1 | Forkhead box Q1 | 65.83 | 191.28 | 3.10 | 4.01e-58 |
| Nrk | Nik related kinase | 54.92 | 903.65 | 16.13 | 1.78e-11 |
| Baiap3 | BAI1-associated protein 3 | 53.49 | 426.34 | 7.87 | 1.14e-54 |
| Bhlhe40 | Basic helix-loop-helix family, member e40 | 52.96 | 220.64 | 4.21 | 3.50e-54 |
| Gjb5 | Gap junction protein, beta 5 | 50.57 | 102.94 | 2.23 | 9.09e-26 |
| Dapp1 | Adaptor for phosphotyrosine and 3-phosphoinositides | 35.14 | 149.67 | 4.07 | 1.91e-33 |
| Epha4 | Eph receptor A4 | 33.56 | 61.58 | 1.73 | 2.20e-16 |
| Procr | Protein C receptor, endothelial | 31.54 | 81.68 | 2.46 | 3.03e-27 |
| Trim16 | Tripartite motif-containing 16 | 30.46 | 352.51 | 11.13 | 4.53e-56 |
| Gpr139 | G protein-coupled receptor 139 | 29.36 | 98.63 | 3.24 | 7.29e-31 |
| Rgs5 | Regulator of G-protein signalling | 28.79 | 705.21 | 23.35 | 2.43e-28 |
| Wnt9a | Wnt Family Member 9A | 25.10 | 45.87 | 1.81 | 1.81e-24 |
| Dll4 | Delta-Like 4 (Drosophila) | 21.08 | 40.86 | 1.61 | 3.19e-23 |
| Elf4 | E74-like factor 4 | 14.85 | 227.91 | 15.07 | 2.98e-23 |
Fold changes and mean expression were obtained using the Bioconductor edgeR package58 with variance between samples by trended estimate. Fold changes is calculated by the gene expression level in adrenal chromaffin precursor cells divided by the gene expression level in sympathetic neuroblasts. Mean expression is reported average count per million (CPM).