Fig. 6. Overexpression of GATA2 can partly induce a gene program involved in megakaryocyte-directed differentiation.

a Associated regulators and functional enrichment (ChIP-seq) in regions with increased GATA2 intensity after CBFβ-MYH11 knockdown (KD). b, c Genomic loci with elevated GATA2 signal show higher expression levels (b) of associated genes and H3K27ac occupancy (c) in the CBFβ-MYH11-knockdown cells. d Motif enrichment in regions with increased GATA2 density. e Gene changes upon GATA2 expression in ME-1 cells. (right) Enriched KEGG pathways of differentially expressed genes after enforced GATA2 expression. f Upregulated cell marker genes induced by GATA2 overexpression. g Correlation of deregulated genes between ME-1 cells overexpressing GATA2 and ME-1 cells upon CBFβ-MYH11 knockdown. Pearson correlation coefficient and p-value are shown