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. 2019 Mar 8;9:3914. doi: 10.1038/s41598-019-40328-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of EGCG treatment on Y maze and novel object recognition memory of Dp16(1)Yey mice. Y maze tests and Novel object recognition memory tests were performed on control wildtype (WT) (n = 14) and Dp16(1)Yey transgenic (TG) (n = 11) and treated WT (n = 16) and TG (n = 8) mice at the end of T1 treatment (P90). (A) Alternation performance in a Y-maze test. (B) Recognition index between familiarisation phase. (C) Quantification of videotracked distance mice travelled on the first day during habituation to the arena for 30 min. (D) Recognition index for mice exploring novel and familiar objects during the second day of novel object recognition memory tests. Recognition index (RI) was defined as RI = (exploration time_{novel objects} − exploration time_familiar objects)/(exploration time_{novel objects} + exploration time_familiar objects). Analysis of exploration time was performed during 12 min; Two ways ANOVA were performed followed by an Holm–Sidak multiple comparison procedure with *p < 0.05.