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. 2018 May 25;26(3):439–448. doi: 10.1016/j.sjbs.2018.05.026

Table 1.

List of Linkers (electron donor and electron acceptor) used at R1, R2, R3, R4 sites of curcumin compound used in generating multiple curcumin analogues.

Compounds R1 R2 R3 R4
CURCUMIN —OH —OCH3 —OCH3 —OH
CUCM-1 —OCH3 —OH —OH —OCH3
CUCM-2 —OCH3 —OCH3 —OH —OCH3
CUCM-3 —OCH3 —OCH3 —OCH3 —OCH3
CUCM-4 —OCH3 —ONH2 —ONH2 —OCH3
CUCM-5 —OH —ONH2 —ONH2 —OH
CUCM-6 —ONH2 —OH ONH(CH2CH3) —ONH2
CUCM-7 —OH —OH —O(OH) —OH
CUCM-8 —OH —ONH2 —OCH3 —OH
CUCM-9 —OH —OH —OH —OH
CUCM-10 —OCH2CH2CH3 —OCH2CH2CH3 —H2CH2CH Created by potrace 1.16, written by Peter Selinger 2001-2019 CH —OCH2CH2CH3
CUCM-11 —OCH2CH2C Created by potrace 1.16, written by Peter Selinger 2001-2019 C —OH —OCH2CH2C Created by potrace 1.16, written by Peter Selinger 2001-2019 C —OH
CUCM-12 —OCH2CH Created by potrace 1.16, written by Peter Selinger 2001-2019 CHCH3 —OCH2CH2C Created by potrace 1.16, written by Peter Selinger 2001-2019 C —OCH2CH2C Created by potrace 1.16, written by Peter Selinger 2001-2019 C —OH
CUCM-13 —OH —OCH2CH2C Created by potrace 1.16, written by Peter Selinger 2001-2019 C —OCH2CH2C Created by potrace 1.16, written by Peter Selinger 2001-2019 C —OH
CUCM-14 —ONH2 —OH —OCH2CH2C Created by potrace 1.16, written by Peter Selinger 2001-2019 C —OH
CUCM-15 —OH —OH —OH —ONH2
CUCM-16 —OCH2CH2C Created by potrace 1.16, written by Peter Selinger 2001-2019 C —OH —OH ONH(OH)
CUCM-17 —OCH Created by potrace 1.16, written by Peter Selinger 2001-2019 CH —ONH2 —OCH Created by potrace 1.16, written by Peter Selinger 2001-2019 CH —OH
CUCM-18 —OH —OCH Created by potrace 1.16, written by Peter Selinger 2001-2019 CH —OH —OCH2(OH)
CUCM-19 —OCH Created by potrace 1.16, written by Peter Selinger 2001-2019 CH —OCH Created by potrace 1.16, written by Peter Selinger 2001-2019 CH —OCH Created by potrace 1.16, written by Peter Selinger 2001-2019 CH —OCH2(OH)
CUCM-20 —OCH Created by potrace 1.16, written by Peter Selinger 2001-2019 CH —OCH Created by potrace 1.16, written by Peter Selinger 2001-2019 CH —OCH2NH2 —OH
CUCM-21 —OCH2NH —OH —OH —OH
CUCM-22 —OCH2NH2 —OCH2NH2 —OCH2NH2 —OCH2NH2(OH)
CUCM-23 —OH —OH —OCH2NH2 —OCH2(OH)
CUCM-24 —OH ONH(OH) —ONH(OH) —OCH2C6H5
CUCM-25 —OCH2(OH) —OH —OH —OH
CUCM-26 —OCH2(OH) ONH(OH) —OH —OH
CUCM-27 —OH ONH(OH) —ONH(OH) —O(CH2(OH)
CUCM-28 —OH —OH —ONH(OH) —OH
CUCM-29 —OCH2(OH) —OCH2(OH) —OCH2(OH) —OCOCH3
CUCM-30 —OCH2NH3 —OCH2(OH) —OH —OCOCH3
CUCM-31 —OCH2NH3 —OH —OCH2(OH) —OH
CUCM-32 —OCH2NH2(OH) —OH —OCH2(OH) —OCOCH3
CUCM-33 —OCH2NH2(OH) —OCH2NH2(OH) —OCH2(OH) —O(OCH3)
CUCM-34 —OCH2(OH) —OCH2(OH) —OCH2NH2(OH) —OH
CUCM-35 —OCH2C6H5 —OCH2C6H5 —OCH2C6H5 —OH
CUCM-36 —OH —OH —OCH2C6H5 —OH
CUCM-37 —OCH2C6H5 —OH —OCH2C6H5 —OCH2(OH)
CUCM-38 —O(CH2(OH) —O(CH2(OH) —O(CH2(OH) —OCH2(OH)
CUCM-39 —O(CH2(OH) —OH —O(CH2(OH) —OH
CUCM-40 —OCOCH3 —OCOCH3 —OH —OH
CUCM-41 —OH —OCOCH3 —OCOCH3 —OCH2(OH)
CUCM-42 —OH —OH —OCOCH3 —OCH2NH3
CUCM-43 —OCOCH3 —OCOCH3 —OCOCH3 —OCH2NH3
CUCM-44 —O(OCH3) —O(OCH3) —OH —OCH2NH2(OH)
CUCM-45 —OH —OH —O(OCH3) —OCH2NH2(OH)
CUCM-46 —O(OCH3) —OH —O(OCH3) —OCH2(OH)
CUCM-47 —O(OCH3) —OH —OH —OCH2C6H5
CUCM-48 —ONH(OCH3) —ONH(OCH3) —OH —OH
CUCM-49 —ONH(OCH3) —OH —ONH(OCH3) —OH
CUCM-50 —ONH(OCH3) —ONH(OCH3) —ONH(OCH3) —OCOCH3