Table 2.

CEA, CYFRA 21-1 and NSE variation according to response to nivolumab

	Median (%)	Range (%)	p-value
CEA
No responder	+ 31	− 79; + 498	0.005
Responder	− 9	− 92: + 88
CYFRA21-1
No responder	+ 72	− 62; + 508	< 0.001
Responder	− 37	− 98; + 2220
NSE
No responder	+ 20	− 64; + 182	0.012
Responder	− 14	− 79; + 71