Table 1.
In vitro antibacterial activity of cationic antimicrobial peptides against methicillin-resistant and -susceptible S. aureus, and antibiotic susceptible and multidrug-resistant P. aeruginosa
| CAMPs | S. aureus (number) | MIC (μg/ml) | MBC (μg/ml) | P. aeruginosa (number) | MIC (μg/ml) | MBC (μg/ml) |
|---|---|---|---|---|---|---|
| LL-37 | MSSA (5) | > 128 | > 128 | AS (6) | 32-64 | 32-64 |
| MRSA (5) | > 128 | > 128 | MDRPA (5) | 32-64 | 32-64 | |
| CAMA | MSSA (5) | 2-4 | 4 | AS (6) | 4-8 | 4-8 |
| MRSA (5) | 4 | 4 | MDRPA (5) | 4-8 | 4-8 | |
| Magainin-II | MSSA (5) | > 128 | > 128 | AS (6) | 128- > 128 | 128- > 128 |
| MRSA (5) | > 128 | > 128 | MDRPA (5) | > 128 | > 128 | |
| Nisin | MSSA (5) | > 128 | > 128 | AS (6) | > 128 | > 128 |
| MRSA (5) | > 128 | > 128 | MDRPA (5) | > 128 | > 128 |
AS antibiotic susceptible, CAMPs cationic antimicrobial peptides, MDRPA multidrug-resistant Pseudomonas aeruginosa, MRSA methicillin-resistant Staphylococcus aureus, MSSA methicillin-susceptible Staphylococcus aureus