Table 2.
MIC (μg/ml) variations of selected antibiotics, CAMPs and antibiotic/CAMP combinations with corresponding FICIs
| Strains | MIC | MIC combination | FICI | ||||
|---|---|---|---|---|---|---|---|
| colistin | LL-37 | CAMA | col/LL-37 | col/CAMA | col+LL-37 | col+CAMA | |
| P. aeruginosa AS1 | 0.25 | 32 | 4 | 0.0625/4 | 0.125/1 | 0.375 | 0.75 |
| P. aeruginosa MDRPA1 | 0.5 | 64 | 4 | 0.125/4 | 0.25/2 | 0.3125 | 1 |
| P. aeruginosa MDRPA2 | 0.5 | 64 | 8 | 0.125/8 | 0.25/2 | 0.375 | 0.75 |
| imipenem | LL-37 | CAMA | imp/LL-37 | imp/CAMA | imp+LL-37 | imp+CAMA | |
| P. aeruginosa AS1 | 16 | 32 | 4 | 8/8 | 4/2 | 0.75 | 0.75 |
| P. aeruginosa MDRPA1 | 32 | 64 | 4 | 8/8 | 32/4 | 0.375 | 2 |
| P. aeruginosa MDRPA2 | 256 | 64 | 8 | 128/16 | 128/4 | 0.75 | 1 |
Note: FICI was defined as follows: FICI ≤0.5, synergy; 0.5 < FICI ≤1.5, additive; 1.5 < FICI ≤ 2.0, indifference; FICI > 2, antagonism
AS antibiotic susceptible, FICI fractional inhibitory concentration index, MDRPA multidrug-resistant Pseudomonas aeruginosa