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. 2019 Mar 8;19:54. doi: 10.1186/s12935-019-0769-2

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Synergistic antiproliferative effect of capsaicin and docetaxel on prostate tumor cells. LNCaP cells (upper panel) or PC3 cells (lower panel) were incubated with increasing doses of docetaxel (DTX), capsaicin (CAP) or the combination of both compounds for 24 h and cell viability was evaluated by MTT. Data represent the mean (n = 3) ± SD. *p < 0.0001 significant difference between treated and control cells by two-way ANOVA and Dunnett’s multiple comparisons test; ^‡p < 0.0001 indicates significant interaction between DTX and CAP treatment. Data were analyzed with CompuSyn software to calculate the combination index (CI)