Table 1.
Upstream regulators in colon identified by Ingenuity pathway analysis based on the comparison between Ercc1−/Δ7 mice receiving A. muciniphila supplementation and control mice
| Upstream Regulator | Activation z-score | p-value of overlap |
|---|---|---|
| ACOX1 | 2.24 | 0.013 |
| Alpha catenin | 2.00 | 0.029 |
| ID3 | 1.98 | 0.030 |
| SOCS1 | 1.95 | 0.040 |
| CDKN2A | 1.72 | 0.025 |
| MYD88 | −2.41 | 0.045 |
| IL1 | −2.38 | 0.049 |
| TNFRSF1B | −2.22 | 0.003 |
| CHUK | −2.21 | 0.017 |
| GATA6 | −2.21 | 0.036 |
| NFKBIA | −2.17 | 0.029 |
| Akt | −2.16 | 0.020 |
| cytokine | −1.99 | 0.000 |
| Nfat (family) | −1.98 | 0.014 |
| CCND1 | −1.98 | 0.044 |
| WNT5A | −1.95 | 0.033 |
| CTNNB1 | −1.95 | 0.037 |
| Tgf beta | −1.94 | 0.010 |
| EGR1 | −1.91 | 0.035 |
| Interferon alpha | −1.78 | 0.004 |
| LTBR | −1.72 | 0.001 |
| STAT3 | −1.71 | 0.024 |
| TCR | −1.60 | 0.029 |
| TNFSF12 | −1.58 | 0.004 |
| TNF | −1.54 | 0.036 |
| SSB | −1.52 | 0.000 |
| IL17A | −1.40 | 0.002 |
| TICAM1 | −1.40 | 0.003 |
| HRAS | −1.39 | 0.031 |
| E2F1 | −1.36 | 0.009 |
| IL6 | −1.34 | 0.005 |
| PRKACA | −1.21 | 0.001 |
| IL1B | −1.21 | 0.003 |
Cut-off values include p < 0.05 and activation z-score < − 1.2 or > 1.2. Upstream regulators in bold are involved in inflammation- and immune-related processes