Table 2.
Upstream regulators in ileum identified by Ingenuity pathway analysis based on the comparison between Ercc1-/Δ7 mice receiving A. muciniphila supplementation and control mice
| Upstream Regulator | Activation z-score | p-value of overlap |
|---|---|---|
| HMGA1 | 1.66 | 0.002 |
| POR | 1.46 | 0.000 |
| SYVN1 | 1.34 | 0.006 |
| CFTR | 1.25 | 0.000 |
| AR | −2.74 | 0.005 |
| NR1I2 | −2.00 | 0.042 |
| BRCA1 | −1.98 | 0.016 |
| CTNNB1 | −1.72 | 0.001 |
| LEP | −1.60 | 0.031 |
| MAPK14 | −1.34 | 0.020 |
| IL10RA | −1.31 | 0.000 |
Cut-off values include p < 0.05 and activation z-score < − 1.2 or > 1.2. Upstream regulators in bold are involved in inflammation- and immune-related processes