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. 2019 Mar 8;10:80. doi: 10.1186/s13287-019-1182-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Improvements in the urodynamic parameters in rats with SUI. A Before treatment (1 week after injury) (A-a, A-b) ALPP of both SUI + USCs-Exo and SUI groups decreased significantly compared with normal group (A-c), 2 and 4 weeks after the injection of USCs-Exo, ALPP of SUI + USCs-Exo group increased greatly (A-e, A-h) compared with SUI group (A-d, A-g). Eight weeks after the injection, ALPP of SUI + USCs-Exo group reached a normal level (A-k). B The ALPP statistics displayed that the differences in ALPP in the SUI group between each time point were not significant, mostly. However, the situation was totally different in the SUI + USCs-Exo group and no difference was found in the ALPP compared with normal group in week 8. C Statistics of MBV showed that on injecting USCs-Exo, the MBV recovered gradually and reached a normal level, finally, while the SUI group did not. D Estimated marginal mean displayed whether injecting USCs-Exo led to different recovery trend and using USCs-Exo caused better recovery (*P < 0.05, **P < 0.01, ***P < 0.001; n.s., no significance)