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. Author manuscript; available in PMC: 2019 Mar 9.
Published in final edited form as: J Med Chem. 2017 Jun 27;60(13):5543–5555. doi: 10.1021/acs.jmedchem.7b00234

Figure 2.

Figure 2.

Diffusion trajectories of cationic (CA4+), anionic (ioxaglate), and nonionic (iodixanol) contrast agents in bovine articular cartilage. (A) Average CECT attenuation values (reported in Hounsfield Units, HU) over the 48-hour time course of diffusion into the cartilage of bovine osteochondral plugs. Each point is reported as the average of six samples (mean ± standard deviation). Each contrast agent was fit to a nonlinear diffusion model (Equation 1). The arrow marks the time when 95% of the equilibrium attenuation is reached. (B) Equilibrium CECT attenuation (normalized by concentration) for each contrast agent in bovine osteochondral plugs (*p<0.0001).