Table 1.
Number of AD cases and controls in the Stage 1 WES dataset and Stage 2 ADGC family-based GWAS datasets.
| Stage | Cohort | Number controls |
Number AD cases |
Total |
|---|---|---|---|---|
| Stage 1 (ADSP WES) |
EA | 4,917 | 507 | 5,424 |
| CH | 177 | 172 | 349 | |
| Total | 5,094 | 679 | 5,773 | |
| Stage 2 (ADGC GWAS) |
MIRAGE (EA) | 704 | 449 | 1,153 |
| NIA-LOAD (EA) | 1,457 | 1,568 | 3,025 | |
| Total | 2,161 | 2,017 | 4,178 | |
| Combined | 7,255 | 2,696 | 9,951 | |
AD = Alzheimer’s Disease; EA = European Ancestry; CH = Caribbean Hispanic; WES = whole exome sequencing; ADSP= Alzheimer’s Disease Sequencing Project; ADGC = Alzheimer’s Disease Genetics Consortium; GWAS = genome-wide association study; MIRAGE = Multi Institutional Research in Alzheimer’s Genetic Epidemiology Study; NIA- LOAD = National Institute on Aging - Late Onset Alzheimer’s Disease Family Study